Anti-Nidogen-1 Neutralizing Antibody: Potential Treatment for Hepatocellular Carcinoma
- Field
- Therapeutic Biologics
- Reference No.
- IP00950
Background
- Hepatocellular Carcinoma (HCC): ~75% of liver cancer
- ~50% of extrahepatic HCC patients have metastasis in lung
- Estimated global incidence rate of liver cancer: 9.3/100k people / year
- Mortality rate: 8.5
- Need a solution to reduce the growth of HCC and minimize metastasis
Technology Overview
- Nidogen-1 specific antibody
- Good for neutralizing/blocking the functions of NID1 in liver cancer cell aggressive properties, tumor formation and metastasis
- Figure 1: Multiple injection of anti-nidogen-1 antibody (Ab#7) can reduce the formation of tumor in mouse model
- Figure 2: Single treatment of anti-nidogen-1 antibody (Ab#7) can reduce metastasis in lung in mouse model
Applications & Opportunity
Applications
- Research Tool for treatment of hepatocellular carcinoma
Opportunity
- Anti-nidogen-1 antibody is ready to delivery for researchers
- Developing treatment regime using anti-nidogen-1 antibody for liver cancer
Patents
- Regular US patent filing
IP Status
- Patent application submitted