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Anti-Nidogen-1 Neutralizing Antibody: Potential Treatment for Hepatocellular Carcinoma

Anti-Nidogen-1 Neutralizing Antibody: Potential Treatment for Hepatocellular Carcinoma
Field
Therapeutic Biologics
Reference No.
IP00950

Background

  • Hepatocellular Carcinoma (HCC): ~75% of liver cancer
  • ~50% of extrahepatic HCC patients have metastasis in lung
  • Estimated global incidence rate of liver cancer: 9.3/100k people / year
  • Mortality rate: 8.5
  • Need a solution to reduce the growth of HCC and minimize metastasis

Technology Overview

  • Nidogen-1 specific antibody
  • Good for neutralizing/blocking the functions of NID1 in liver cancer cell aggressive properties, tumor formation and metastasis
  • Figure 1: Multiple injection of anti-nidogen-1 antibody (Ab#7) can reduce the formation of tumor in mouse model1
  • Figure 2: Single treatment of anti-nidogen-1 antibody (Ab#7) can reduce metastasis in lung in mouse model
    2

Applications & Opportunity

Applications

  • Research Tool for treatment of hepatocellular carcinoma

Opportunity

  • Anti-nidogen-1 antibody is ready to delivery for researchers
  • Developing treatment regime using anti-nidogen-1 antibody for liver cancer

Patents

  • Regular US patent filing

IP Status

  • Patent application submitted

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