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Palladium (II) Complexes in Anti-cancer

Palladium (II) Complexes in Anti-cancer
Therapeutic Chemicals
Reference No.

Key Problem and Market Opportunity

  • There has been a growing interest in expanding the applications of palladium complexes in anti-cancer.
  • The main challenge for the development of anticancer palladium(II) complexes is their high reactivities toward sulfur-containing biomolecules, such as glutathione (GSH), and ease of substitution reactions under physiological conditions, leading to low in vivo stability and multiple speciation that complicates the potential therapeutic applications.

Key Advantages of the Technology

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  • High stability in vitro and in the presence of physiological thiols
  • Potent cytotoxicity against cancer cells
  • Effective in vivo anticancer activities 
  • Involve induction of mitochondrial dysfunction and inhibition of EGFR signalling pathways

Potential Product and Services

  • Platform technology for developing Palladium (II) N-heterocyclic carbene (NHC) complexes
  • Anti-cancer drug

Development Status and IP Strength

  • PCT Application No. PCT/CN2016/093965
IP Status
  • Patent application submitted

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